U.S. & Canadian Airport Distances
Before departing, make sure you have all your affairs, business and personal, in order. Ensure you are not stressed-out with excitement or worry, and not tired or hungover from a function the night before. Get plenty of exercise in the days prior to departure and try to avoid sickness such as the flu, colds and so on. If you have a cold, flying will probably make it worse - ideally you should delay the trip. Get a good night's sleep just prior to departure.
There is some evidence that flying westwards causes less jet stress than flying eastwards. Most travelers think daytime flights cause less jet stress.